Maturation Matters…

The only difference is the plate.

CELLvo™ Matrix Plus promotes rapid maturation of hiPSC-CMs in as little 7 days. Widespread adoption of hiPSC-CM assays for pre-clinical cardiotoxicity screening has been stalled until maturation of the human heart muscle cells was solved-using CELLvo™ Matrix Plus coated cell culture dishes.

Relative to typically used Matrigel extracellular matrix (ECM), hiPSC-CMs plated on CELLvo™ Matrix Plus have enhanced maturation indicated by multi-nucleation (blue), ordered sarcomeres (red) and intercellular localization of gap junction proteins (green). These hiPSC-CMs, plated on CELLvo™ Matrix Plus ECM resemble the shape, structure and function of native human heart muscle cells. Now high throughput screening for cardiotoxicity can be performed in vitro using mature human cardiomyocytes.

Widespread adoption of hiPSC-CMs is a giant step towards Reducing, Refining and Replacing the use of animals in the drug discovery pipeline.

“Evaluate contractility, metabolism and electrophysiology using Custom Coated CELLvo™ Matrix Plus plates. For example, Use CELLvo™ plates to run a Seahorse assay for examining metabolic function.”

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CELLvo™ Matrix Plus

from $283.00

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These hiPSC-CMs plated on CELLvo Matrix Plus have enhanced maturation indicated by multi-nucleation (blue) and ordered sarcomeres (red)

A new paper, entitled "*Human perinatal stem cell derived extracellular matrix enables rapid maturation of hiPSC-CM structural and functional phenotypes*," provides data that CELLvo™ Matrix Plus enabled hiPSC-CM maturation in seven (7) days

ADDITIONAL RESEARCH PRODUCTS FROM STEMBIOSYS:

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CELLvo™ Cells

CELLvo™ Matrices

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CELLvo™ Human Atrial Cardiomyocytes

from $1,255.54

CELLvo™ Human induced pluripotent stem cell-derived Atrial Cardiomyocytes (hiPSC-aCMs) are chamber specific cardiac myocytes that are differentiated from human pluripotent cells generated by non-integrating vectors. These cells are non-genetically modified, chamber specific, purified by negative selection using magnetic beads, and capable of rapid maturation when plated onto CELLvo™ Matrix Plus. Purchase cells alone or bundle your order with a sleeve of CELLvo™ Matrix Plus for an added discount.

CELLvo™ NeuroMatrix

from $819.55

NeuroMatrix is an extracellular matrix produced in vitro by primary human astrocytes. This product is composed of proteins secreted and assembled by astrocytes during cell culture. In vivo, astrocytes are the most abundant glial cell type and are essential for neuron survival. This astrocyte-derived extracellular matrix provides support for a variety of iPSC-derived and primary neural cell types in mono and co-culture, including cortical neurons, cortical astrocytes, microglia, spinal motor neurons, and neural stem cells. It can be used for a variety of applications, including excitotoxicity studies and neurite outgrowth.

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CELLvo™ Matrix Plus

from $283.00

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CELLvo™ Matrix Plus (Imaging) - with Ultra Flat Coverslip Bottom (5 -96 WPs)

$1,061.31

CELLvo™ Matrix Plus technology is now available on cell culture plates with Coverslip bottoms and black walls. These specialized plates are an extension of the CELLvo™ Matrix line and are ideal for high end microscopic analysis of fixed or living cells. This stem cell-derived ECM has been shown to enhance the isolation, growth and differentiation of a variety of different cell types including induced pluripotent stem cells (iPSCs). Consistent with all other CELLvo™ Matrix products, CELLvo™ Matrix Plus is easy to use requiring only a brief rehydration step prior to use. This cell culture substrate provides a native, young microenvironment which can be used as a more biologically relevant culture environment for in vitro studies.

CELLvo™ Matrix Plus technology with coverslip bottoms are ideal for cell microscopy due to black walls and optically flat bottom. These specialized plates are known for low well-to-well crosstalk in fluorescence microscopy. The polymer coverslip exhibits low autofluorescence similar to that of glass. Flat plate bottom makes it ideal for high throughput applications.

For Research Use Only. Not intended for diagnostic or therapeutic applications.

CELLvo™ Matrix Plus (Imaging)- with black walls and Advanced TC (5- 96 WPs)

$803.15

CELLvo™ Matrix Plus Technology is now available on cell culture plates with black walls especially designed for fluorescent imaging. These specialized plates are an extension to the CELLvo™ Matrix line and are ideal for high throughput applications in cell based assays. The stem cell-derived ECM has been shown to enhance the isolation, growth and differentiation of a variety of different cell types including induced pluripotent stem cells (iPSCs). Consistent with all other CELLvo™ Matrix products, CELLvo™ Matrix Plus is easy to use requiring only a brief rehydration step prior to use. This cell culture substrate provides a native, young microenvironment which can be used as a more biologically relevant culture environment for your in vitro studies.

CELLvo™ Matrix Plus Technology with black walls provide improved cell adherence. The Advanced TC flat bottom with low autofluorescence is manufactured without adhesives or solvents and is ideal for sensitive adherent cells. The specialized properties reduce the risk of sample carryover and cross-contamination.

For Research Use Only. Not intended for diagnostic or therapeutic applications.

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CELLvo ™ ChondroMatrix

from $315.52

CELLvo™ ChondroMatrix is an extracellular matrix (ECM) synthesized in vitro by human articular chondrocytes. This product is composed of proteins that were secreted and assembled by human articular chondrocytes during the production of the matrix.

The final product is cell-free with only an ECM attached to the surface of the culture vessel. When you are ready to culture cells on the matrix, simply rehydrate the dish for one hour at 37 degrees Celsius. This cell culture substrate provides a native microenvironment, which can be used for rapid expansion of high quality human articular chondrocytes (HC-a).

The images below display cells grown on ChondroMatrix, an illustration of proteins present on the dish, and the production of the matrix. The table demonstrates how cells grown on CELLvo™ ChondroMatrix express a higher Col2/Col1 ratio compared to cells grown on standard tissue culture plastic.