BM-HPME® IS AN EXTRACELLULAR MATRIX (ECM) OF PROTEINS SYNTHESIZED IN VITRO BY BONE MARROW STROMAL CELLS. THIS PRODUCT IS COMPOSED OF MORE THAN 150 PROTEINS THAT WERE SECRETED AND ASSEMBLED BY BONE MARROW CELLS DURING THE PRODUCTION OF THE HPME®.
The final product is cell free with only the ECM attached to the surface of the culture vessel. This cell culture substrate provides a native three-dimensional microenvironment which can be used for rapid expansion of high quality mesenchymal stem cells (MSCs).
Product Use. NOT FOR HUMAN USE. This product is for research use only. Not to be used for diagnostic or therapeutic applications.
Safety Information. Wear appropriate protective eyewear, clothing, and gloves. Handle in accordance with established bio-safety practices.
Storage and Stability. Store at 2-8°C and avoid extended exposure to light.
Reconstitution. Rehydrate using phosphate buffered-saline (PBS)or preferred media for 1 hour at 37 °C prior to use (2 ml for 6wp, 15 ml for T75, 30 ml T150, and 10 ml for 100 mm). Wash 2X with PBS or media before seeding cells.
CLICK HERE to view the downloadable Product Specifications pdf.
CLICK HERE to view the downloadable Safety Data Sheet pdf.
CLICK HERE to view the downloadable General Rehydration Protocol pdf.
Lai, Y et al. (2010) Reconstitution of marrow-derived extracellular matrix ex vivo: a robust culture system for expanding large-scale highly functional human mesenchymal stem cells. Stem Cells Dev 19: 1095-1107.
Chen, XD et al. (2007) Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts. J Bone Miner Res 22: 1943-1956.
This product may be covered in part or in whole by US Patent #’s 8,084,023 ; 8,388,947 ; 8,961,955
Limited Use Label License: Research Use Only. The purchase of this product conveys to the purchaser the limited, nontransferable right to use the purchased amount of the product only to perform internal research for the sole benefit of the purchaser. No right to resell this product or any of its components is conveyed expressly, by implication, or by estoppel. This product is for internal research purposes only and is not for use in commercial applications of any kind, including, without limitation, quality control and commercial services such as reporting the results of purchaser’s activities for a fee or other form of consideration. For information on obtaining additional rights, please contact firstname.lastname@example.org or StemBioSys, Inc., 3463 Magic Drive, Ste 110, San Antonio, TX 78229.
Limited product warranty: StemBioSys warrants that this product will be free of mechanical defects (cracks in the plastic or torn or ripped outer packaging).
If you have any questions about this product, please contact StemBioSys at email@example.com.